Erratum for Abdolrasouli et al., Genomic Context of Azole Resistance Mutations in Aspergillus fumigatus Determined Using Whole-Genome Sequencing
نویسندگان
چکیده
Alireza Abdolrasouli,a,b Johanna Rhodes,c Mathew A. Beale,c,d Ferry Hagen,e Thomas R. Rogers,f,g Anuradha Chowdhary,h Jacques F. Meis,e,i Darius Armstrong-James,a Matthew C. Fisherc National Heart & Lung Institute,a Department of Medical Microbiology, Charing Cross Hospital,b and Department of Infectious Disease Epidemiology,c Imperial College London, London, United Kingdom; Institute of Infection and Immunity, St. George’s University of London, London, United Kingdomd; Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlandse; Department of Clinical Microbiology, Trinity College Dublin, Dublin, Irelandf; St. James’ Hospital, Dublin, Irelandg; Department of Medical Mycology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, Indiah; Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlandsi
منابع مشابه
Genomic Context of Azole Resistance Mutations in Aspergillus fumigatus Determined Using Whole-Genome Sequencing
UNLABELLED A rapid and global emergence of azole resistance has been observed in the pathogenic fungus Aspergillus fumigatus over the past decade. The dominant resistance mechanism appears to be of environmental origin and involves mutations in the cyp51A gene, which encodes a protein targeted by triazole antifungal drugs. Whole-genome sequencing (WGS) was performed for high-resolution single-n...
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Azole compounds are the primary therapy for patients with diseases caused by Aspergillus fumigatus. However, prolonged treatment may cause resistance to develop, which is associated with treatment failure. The azole target cyp51A is a hotspot for mutations that confer phenotypic resistance, but in an increasing number of resistant isolates the underlying mechanism remains unknown. Here, we repo...
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Invasive aspergillosis (IA) due to Aspergillus fumigatus is a major cause of mortality in immunocompromised patients. The discovery of highly fertile strains of A. fumigatus opened the possibility to merge classical and contemporary genetics to address key questions about this pathogen. The merger involves sexual recombination, selection of desired traits, and genomics to identify any associate...
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The emergence of azole-resistant strains of Aspergillus fumigatus during treatment for aspergillosis occurs by a mutation selection process. Understanding how antifungal resistance mechanisms evolve in the host environment during infection is of great clinical importance and biological interest. Here, we used next-generation sequencing (NGS) to identify mutations that arose during infection by ...
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The increasing incidence of azole resistance in Aspergillus fumigatus causing invasive aspergillosis (IA) in immunocompromised/hematological patients emphasizes the need to improve the detection of resistance-mediating cyp51A gene mutations from primary clinical samples, particularly as the diagnosis of invasive aspergillosis is rarely based on a positive culture yield in this group of patients...
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